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Abstract Inability to achieve therapeutic concentrations of a medication in the brain due to the blood brain barrier (BBB) is the major cause of treatment failure for most brain diseases
For histologic examination, organs were fixed in 10% buffered formalin, followed by paraffin embedding
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The elevation in IGF-1 is associated with increased thickness of dermal tissue, potentially due to the anabolic actions of growth hormone and IGF-1 on collagen-producing cells like fibroblasts
Interestingly, we found TST induced ferroptosis by reducing the GPX4 expression, consistent with previous studies [31,32,33]
