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Acute exposure to LPS induces long-lasting changes in airway macrophages, resulting in an innate immune memory phenotype that protects against bacterial pneumonia (23)

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The compound 37 connected through an ether linkage show 713-fold decrease in the inhibitory ability (IC 50 = 378.11 M) indicate the sulfur atom is very important in chelating with the copper ions and contributes in a greater inhibition tyrosinase activity