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The preclinical evidence is robust, consistent, and mechanistically plausible, but the gap between rat sciatic nerve transection models and human diabetic neuropathy is significant
[DOI] [PubMed] [Google Scholar] 32.Moraes LB, Murakami AH, Fontes B, Poggetti RS, van Rooijen N, Younes RN, Heimbecker AM, Birolini D
Funding This work was supported by Priority Union Foundation of Yunnan Provincial Science and Technology Department and Kunming Medical University (No.202201 AY070001 - 066), Funding of the"famous doctors"project of the support plan for the talents of Xingdian (No.RLMY20220005), The scientific and technological innovation team of Kunming Medical University (CXTD202209), Yunnan Provincial Endocrinology and Metabolism Clinical Medicine Center (YWLCYXZXXYS20221005),Clinical Collaboration Project of Traditional Chinese and Western Medicine for Major Difficult Diseases of Yunnan Province (300073)

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The EDSS score is greatly impacted by a patients ambulatory status and may underrepresent other important deficits, such as hand dexterity

28,29 Symptoms may initially be mild, but they gradually worsen as the disease progresses
