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In orthotopic and postsurgical TNBC mouse models, MND-ART-GEL significantly inhibited tumor growth and recurrence, remodeled the immunosuppressive tumor microenvironment, enhanced CD8+ T-cell infiltration, dendritic cell maturation, and M1 macrophage polarization, reduced PD-1/PD-L1 expression on CD8+ T cells, and promoted the secretion of immune-related cytokines
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The present study aimed to introduce and optimize a protocol for inducing leaf callus and eliciting enriched synthesis of bonducellin compound
