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Data analysis All statistical analyses were performed in RStudio

It is often advisable to start with a lower dose (e.g., one capsule daily) and gradually titrate up to the full dose as tolerated

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The sleep deprivation pro-atherogenic effect in animal model of sleep fragmentation is mediated, at least in part, by reduced hypothalamic release of hypocretin (i.e., orexin), a wake-inducing neuropeptide, which limits the production of leukocytes (monocytes and neutrophils) and atherosclerosis development, and has been inversely associated with the risk of myocardial infarction, heart failure, and obesity 205

doi: 10.1038/s41467-023-40182-4