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Exosomes deliver new antigens to neighboring immune cells, which initiate inflammation and activate autoreactive T cells, so the chemical-induced stress in melanocytes initiates an autoimmune response that results in their destruction (Figure 2, reviewed in 80, 81 )

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The majority of DARs have immediate homologous counterparts in the mouse and human genomes, indicating that these regions are highly conserved over evolutionary time

However, it is also possible that other indirect or noncell-autonomous mechanisms may additionally contribute to increased opioid tone in red-haired Mc1r mice

Clin Endocrinol (Oxf) 65:198205 [DOI] [PubMed] [Google Scholar] Wang CL, Liang L, Wang HJ, Fu JF, Hebebrand J, Hinney A 2006 Several mutations in the melanocortin 4 receptor gene are associated with obesity in Chinese children and adolescents