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eLife 11 , e70816 (2022)

N., Miasoedov, N

LDHB KD significantly downregulated GSH synthesis genes, such as glutamate-cysteine ligase (GCL) catalytic and modifier subunits (GCLC and GCLM), GSH synthetase (GSS), and GSH reductase (GSR), as well as the GSH gene signature ( Figure 1f

Of particular interest in regard to the molecular mechanisms for spine structural changes will be analyses of actin dynamics regulators in addition to drebrin, such as the aforementioned CaM kinase II, calcineurin, -actinin, myosins V and VI, Arp2/3 and Rac1, cofilin and LIMK, and MARCKS and PI(4,5)P 2 (Knobloch and Mansuy, 2008

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Leyden JJ, Stephens TJ, Finkey MB, Appa Y, Barkovic S