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In addition, mouse mast cell protease (MMCP)-6 and MMCP-7 triggered the release of IL-33 from glia-neuron mixed cultures and primary mouse astrocytes

This influences chloroplast to nucleus signalling pathways via the redox-sensitive transcription factor Rap2.4a (Shaikhali et al

afzelii strains colonized joint tissues in mice at significantly lower levels than did DbpA from a B

In addition to murine models, larger animals such as rabbit, dog, sheep, and bovine have played an important role as their IVDs are more similar in size and mechanical load to human IVDs, particularly in studies involving biomechanical changes over time and the application of pre-clinical therapies (Sakai and Andersson, 2015)