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Ectopic overexpression of NAMPT also activated STAT3

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MOTS-c treatment promoted AMPK phosphorylation and PGC-1 expression, while inhibition of AMPK activation with compound C or a specific siRNA suppressed PGC-1 expression, as shown by western blot analysis [52]

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24 weeks, 68 weeks (trial-length) 2 30 mL bottles 24 weeks: Roughly 1218 mL used

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In vivo study proved the sufficient Dox release ability of M14 in TME contributed to significant tumor growth suppression and improved survival in the C26 tumor-bearing mouse model

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