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The American Academy of Pediatrics and the American Diabetes Association have both recently recommended screening for abnormalities in glucose metabolism in children with a body mass index (BMI) at or above the 95th percentile [21,22]

Using in vivo and ex vivo ischemia-reperfusion models, ozone treatment was shown to reduce myocardial injury by regulating ferroptosis-related proteins and transcription factors, particularly enhancing Nrf2 nuclear translocation, thereby exerting cardioprotective effects ( 3.1.5 Mechanisms of ferroptosis in myocardial ischemia-reperfusion injury In pathological conditions such as myocardial ischemia-reperfusion injury, the Nrf2/Keap1 pathway becomes dysregulated, leading to the dissociation of Nrf2 from Keap1 and its subsequent translocation into the nucleus

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Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers

References 1.Townsend D.M., Tew K.D