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Increase of intracellular ROS generation exacerbates intrinsic pathway of apoptosis which is usually followed by a loss of mitochondrial membrane potential [149]

P values are from FDR-adjusted two-sided t-tests from MetaboAnalyst

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Differential expression analysis To identify differentially expressed genes or evaluate the significant difference of one gene between two groups, we used the Wilcoxon test in R, with multiple hypothesis correction using the Benjamini-Hochberg procedure

Author Contributions Guifei Chen: conceptualization (equal), writing original draft (equal)

The master antioxidant that recharges other antioxidants Supports healthy liver function Promotes bright, youthful skin Can lighten dark spots in skin and diminish the appearance of wrinkles Suppresses the melanin production that can lead to hyperpigmentation Protects skin cells from the damaging effects of UV rays, guarding against sagging and wrinkles Ingredients LIPOSOMAL GLUTATHIONE 1000mg Essential phospholipids 500 mg Phosphatidyl Choline Vegan Gluten free Non-GMO Sugar-free Hexane free Dairy free No fillers or colorants No artificial flavors Dosage As a dietary supplement, take one packet 1 to 2 times per day or as directed by a healthcare practitioner