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Among them, imidazole ketone erastin (IKE) had a stronger inhibitory effect and greater metabolic stability than erastin, which led IKE to be an excellent candidate for investigating ferroptosis initiation in vivo and in vitro (Hirschhorn and Stockwell 2019)

Mechanical stretch: physiological and pathological implications for human vascular endothelial cells

Fer-1 increased viability to 90% of cells under Cys 2 starvation and in BSO-treated cells, and to 70% in erastin-treated cells (Fig

doi: 10.1038/s41572-019-0097-9 2 CallaghanBCHurJFeldmanEL

DNA content was measured using a CytoFLEX flow cytometer (Beckman)

Oral or capsules : Between 100 to 50 mcg, one to two times daily