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, Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance

Siponimod is currently only approved for active SPMS as the subgroup analyses from EXPAND study failed to show a statistically significant improvement in 3-month confirmed disability progression among people with no relapses in the previous 2 years [263]

Wiley, 2023

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Until such trials are completed, the compound remains experimental