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In a phase 2 trial, once-weekly cagrilintide produced dose-dependent weight reductions in people with overweight or obesity, which is what moved the amylin pathway into serious combination development ( Lau et al., Lancet 2021 )

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In vitro , in a colon epithelial cell line (Caco-2), TNF-induced increases in TJ permeability were associated with increased nuclear factor kappa beta (NF-B) activation and nuclear translocation of NF-B p65 [13]