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They were initially defined as secretory GPX, but later studies have shown that both enzymes are localized to the endoplasmic reticulum and are necessary enzymes involved in the oxidative folding of endoplasmic reticulum proteins (Figure 8)

Individuals with gastrointestinal disorders like celiac disease, Crohn's disease, or surgical alterations in the gastrointestinal tract may also experience impaired B12 absorption

Scale-Up and High-Throughput Reconstitution Methods Standardize the solvent batch, volume added, and incubation time across every vial so each preparation matches

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