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After TMA is absorbed in the intestines, the FMO3 enzyme converts it into TMAO (trimethylamine-N-oxide).[ref] TMAO (trimethylamine-N-oxide) is the oxidized form of trimethylamine (TMA)

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Observations such as eosinophilic muscle fibers, disruption of intercalated discs, and severe mitochondrial degradation point to a progressive degenerative process that compromises cardiac tissue integrity

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ALCAR was either administered orally (4 g/day for 90 days) in four trials or intravenously (4 g/day for three days) in one trial

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