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The continuous systemic inflammation generated by this vascular damage further depletes the body's already compromised antioxidant reserves, perpetuating the cycle of chronic illness and making recovery incredibly difficult without targeted biochemical intervention

While selenium deficiency is a major etiological factor of Keshan disease (54), the seasonal and annual variation in disease occurrence suggested that other factors, especially an infectious agent, might be involved in addition to selenium deficiency (55)

Among typical behaviors assessed in mice and rats, directly related to the core symptoms of autism, are deficits in social interaction (i.e., three-chamber social approach paradigm), deficits in communication (i.e., analysis of ultrasonic vocalizations), increased repetitive/stereotyped motor behaviors (i.e., self-grooming or marble burying), and persistence on sameness and restricted interests (i.e., perseveration in the T maze or water maze) [23,24]

mCSM: predicting the effects of mutations in proteins using graph-based signatures