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Here is an honest comparison of how the two approaches differ, and when each one makes the most sense

J Clin Endocrinol Metab 76:309317 Beshyah SA, Kyd P, Thomas E, Fairney A, Johnston DG (1995) The effects of prolonged growth hormone replacement on bone metabolism and bone mineral density in hypopituitary adults

In the case of other plants, no constant B12 content has yet been determined

Increased proteolysis of insulin-like growth factor-binding protein-3 (IGFBP-3) in noninsulin-dependent diabetes mellitus serum, with elevation of a 29-kilodalton (kDa) glycosylated IGFBP-3 fragment contained in the approximately 130- to 150-kDa ternary complex

Lees et al., 1988