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Tissue Specificity and Metabolic Effects Importantly, these metabolic effects appear to be tissue-specific to adipose tissue, as studies have not shown similar effects on muscle protein metabolism or bone growth

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Semaglutide primarily targets GLP-1 alone, while Tirzepatide combines GLP-1 and GIP receptor activity, giving it a broader incretin signalling profile

GJS, SB, and SPH were partly supported by the Research Council of Norway through its Centres of Excellence funding scheme (project number 262613), and financial support from UiO:Life Science (Project MORGI-20493) is gratefully acknowledged