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Conflicts of Interest The author declares no conflicts of interest in this work

ICIs work by blocking the interactions between immune checkpoints such as CTL-associated protein 4 (CTLA-4), programmed cell death-1 (PD-1), and programmed cell death ligand-1 (PD-L1) and their ligands, which releases the inhibitory brakes of T cells and results in the robust activation of immune responses (Fig

According to a study, alterations in the calcium signaling of hippocampus neurons in the AD mice model occurred before the development of amyloid plaques or other symptoms of the disease [20]

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Nicotinamide metabolism alterations in bladder cancer: preliminary studies