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J Clin Pathol (2008) 61:438

Louandre C et al

12 15] 4 Case Reports/Case Series [16 19] 1 Prospective Trial [20] Dexemedetomidine does not protect against withdrawal seizures and should not be used as monotherapy Ketamine 1 Retrospective Review [21] Clinical Bottom Line Phenobarbital, propofol, and dexmedetomidine have been shown to reduce benzodiazepine requirements in AWS Nothing has proven to shorten AWS duration or ICU LOS Dexmedetomidine does not protect against withdrawal seizures and should not be used as monotherapy References: Rosenson J et al

1 2 "A model for the reaction mechanism of the transglutaminase 3 enzyme"

there is no minimum clinically important difference validated for this scale

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