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Loss of NAD + levels results in impairment of mitochondria function, which leads to failure of essential metabolic processes (Reid et al., 2018)

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(2020, Drug Testing and Analysis) developed an immunopurification + high-resolution mass spectrometry method to detect Long R3-IGF-I and Des(1-3)-IGF-I in athlete samples establishing that IGF-1 LR3 is detectable by current anti-doping methods