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Klinefelter syndrome: more than hypogonadism

For frozen sections, 4% paraformaldehyde-fixed brains were mildly shaken in 20% sucrose solution for 6 h and then 30% sucrose solution overnight at 4 C

MOTS-c is a mitochondrial-derived peptide that plays a key role in regulating metabolic function, enhancing fat metabolism, and improving energy levels by optimizing mitochondrial efficiency

Adequate sleep is also crucial, as glutathione production and recycling occur during rest periods

PPP is also involved in NETs formation induced by PMA and AF, which was demonstrated by blocking glucose-6-phosphate dehydrogenase of PPP by adding 6-aminonicotinamide (6-AN) [26]

In addition to their role in ECM assembly, they are also involved in ECMcell interaction by acting as ligands for cell surface receptors such as integrins