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doi: 10.3389/fimmu.2021.646159 101 YajimaTYoshiharaKNakazatoKKumabeSKoyasuSSadSet al

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[DOI] [PubMed] [Google Scholar] 82.Wang Z.-Y., Liu Y.-Y., Liu G.-H., Lu H.-B., Mao C.-Y

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10.1179/1476830514Y.0000000110 110 Navarro-CruzA

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2016;41(7):e2234

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Reductions in fat mass without concomitant lean mass losses and decreases in plasma leptin and insulin were noted with 53.4 nmol/day doses of AZD2820 ( AZD2820 entered a phase 1 clinical trial in 2011 to investigate the safety and tolerability in healthy male volunteers of single ascending doses up to 12 mg, SC QD ( Table 2 ) ( The absence of weight loss coupled with partial agonism on hMC4R suggests that an efficacious dose of AZD2820 was not achieved

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