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erinaceus supplementation on cognitive function in 50- to 80-year-old Japanese men and women with mild cognitive impairment (MCI)

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There is a well-recognized phenomenon in gut-hormone pharmacology whereby a signal that potently slows gastric emptying on first exposure gradually loses that particular effect under continuous stimulation, even as its central appetite-suppressing effect persists

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This dysfunction is driven by inflammation and oxidative stress, which in turn alter adipogenesis, lipolysis, and insulin and leptin signaling, contributing to obesity and its comorbidities