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Molecular Weight: 159.21 g/mol

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It has been demonstrated that GSTP inhibits the phosphorylation of VE-cadherin through the GS-ylation of Srcthe upstream tyrosine kinase of VE-cadherinmaintaining the endothelial barrier function [53]

Tirzepatide shows promising hepatic effects in ongoing MASLD trials, and semaglutide has demonstrated modest liver fat reduction, but neither approaches the retatrutide benchmark

its cell-free supernatant improved hepatic lipid accumulation and inflammation in animal models by increasing -oxidation gene expression and inhibiting inflammatory responses, indicating it holds promise as a candidate for novel microbiome-based therapeutic strategies

1 H NMR (400 MHz, DMSO- d 6 ) 12.44 (s, 1H), 11.00 (s, 1H), 9.93 (s, 1H), 7.64 (d, J = 7.3 Hz, 1H), 7.56 (dt, J = 14.8, 6.8 Hz, 2H), 7.41 (d, J = 3.4 Hz, 1H), 6.73 (d, J = 2.5 Hz, 1H), 5.14 (dd, J = 13.2, 5.0 Hz, 1H), 4.404.19 (m, 2H), 4.07 (s, 2H), 3.53 (d, J = 12.0 Hz, 2H), 3.09 (t, J = 6.8 Hz, 2H), 2.99 (dd, J = 10.5, 5.0 Hz, 2H), 2.952.83 (m, 3H), 2.74 (t, J = 12.0 Hz, 1H), 2.60 (d, J = 17.5 Hz, 1H), 2.45 (dd, J = 13.3, 8.8 Hz, 1H), 2.02 (d, J = 12.5 Hz, 3H), 1.981.81 (m, 2H), 1.62 (dt, J = 14.1, 5.9 Hz, 4H), 1.41 (s, 2H), 1.28 (s, 6H), 1.19 (s, 9H)