lps glutathione transferase Omega 1 is required for the lipopolysaccharide-stimulated induction of NADPH oxidase 1 and the production of reactive oxygen species in macrophages Full article: Glutathione Trisulfide Prevents

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Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: A randomized, controlled trial

L-theanine supports relaxation and mood by increasing alpha-wave activity, and levels of serotonin, dopamine, and GABA in the brain.* L-theanine also has been shown to block binding of L-glutamic acid to excitatory glutamate receptors in the brain.* Glutamate receptor subtypes have been shown to modulate excitability associated with anxiety, while in depression, a hyperfunctioning glutaminergic system also may be an issue.* Continuous administration of L-theanine has been shown to increase expression of brain-derived neurotrophic factor (BDNF) protein, a protein which plays a role in neural plasticity and neurogenesis.* *These statements have not been evaluated by the Food and Drug Administration

J Alzheimers Dis 66:517532 Matsuzawa D, Obata T, Shirayama Y, Nonaka H, Kanazawa Y, Yoshitome E, Takanashi J, Matsuda T, Shimizu E, Ikehira H, Iyo M, Hashimoto K (2008) Negative correlation between brain glutathione level and negative symptoms in schizophrenia: a 3T 1H-MRS study

Glutamate uptake

This review highlights three critical pathways, the gutbrain, erythrocytebrain, and kidneybrain axes as significant contributors to systemic dysfunction