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Prodrugs of GST Both conventional chemotherapeutic and targeted agents have well-established toxicity profiles, with a wide range of adverse effects, eg, bone-marrow suppression, gastrointestinal toxicity, immunosuppression, gastrointestinal toxicity, hepatotoxicity, and cardiotoxicity

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Short-term pharmacotherapy has not been shown to produce longer-term health benefits and cannot be generally recommended

Glutathione can turn this suppression around