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Nrf2-driven antioxidant programs including the HO-1/Nrf2/GPX4 axis have demonstrated protective effects in various diseases such as stroke and renal injury ( At the post-transcriptional level, GPX4 is regulated by non-coding RNAs
This indicates that melatonin may act on several points in the antioxidant defense system, not exclusively on GSH-Px40, which is also evident in drug induced liver injuries

26 Both Tiki and Notum act as enzymes to inactivate Wnt proteins

[DOI] [PubMed] [Google Scholar] 249.Pavlin D., Cemazar M., Cr A., Sersa G., Pogacnik A., Tozon N
