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IL-1 receptor antagonist (IL-1RA) acts as an anti-inflammatory cytokine

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In contrast, systemic bioavailability following subcutaneous or intramuscular administration can vary widely, typically ranging from 20% to 100%, depending on factors such as enzymatic degradation at the injection site, absorption kinetics, and lymphatic uptake [9]

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Where possible, include rescue/chelator reversibility (e.g., LIP by calcein de-quench) to prove on-target signal

Nelson, DB, Nguyen Q, Erasmus JJ, Tayob N, Mitchell KG, Hofstetter WL, Sepesi B, Walsh GL, Vaporciyan AA, Swisher SG, Antonoff MB , Roth JA, Rice DC, Mehran RJ