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Back to Journals Neuropsychiatric Disease and Treatment Volume 22 Current Evidence of Acetyl-L-Carnitine Use in Mood Disorders-: A Systematic Review and Meta-Analysis Authors Kumar R , Hashempour Z, Shahriarirad S, Shahriarirad R, Hassett LC, Singh B , Croarkin PE , Veldic M, Frye MA, Pagali SR Received 6 January 2026 Accepted for publication 12 March 2026 Published 3 June 2026 Volume 2026:22 586506 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Roger Pinder Rakesh Kumar, 1 Zahra Hashempour, 2 Sara Shahriarirad, 2 Reza Shahriarirad, 3 Leslie C Hassett, 4 Balwinder Singh, 1 Paul E Croarkin, 1 Marin Veldic, 1 Mark A Frye, 1 Sandeep R Pagali 5 1 Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA

This suppression leads to the activation of GLUD-mediated glutamine anaplerosis

For this very reason, most B5 supplements are sold as a B-complex vitamin or multivitamin

Nicotinic acid elevates total HDL by an unknown mechanism, but is associated with an increase in serum levels of Apo A-I and lipoprotein A-I, and a decrease in serum levels of Apo-B

Exogenous antioxidantsDouble-edged swords in cellular redox state: Health beneficial effects at physiologic doses versus deleterious effects at high doses