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Regular doctor visits are required to monitor the disease and modify treatment as appropriate

These microbial changes correlate with higher lipopolysaccharide (LPS) and lower superoxide dismutase-1 levels (59, 60), which can lead to microbial translocation, systemic inflammation, and increased permeability of both the intestinal and blood-brain barriers (BBB), creating a vicious cycle (6165)

The FDA-approved NMDA receptor antagonist ketamine has been useful in Mecp2 knockout mice to improve RTT-like phenotypes (Kron et al., 2012)