methionine restriction glutathione and lifespan control Methionine - Metabolite - biocrates

During aging, mtNOS switches to uncoupled mode, that involved loss of the ability to convert L-arginine into L-citrulline with the release of NO, instead, it catalyzes a transfer of electrons from NADPH to molecular oxygen with the formation of a superoxide anion radical (Roe and Ren, 2012

, & Ji, H

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(350) Massey, L

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