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These studies are particularly encouraging given the great potential of immunotherapy in anti-cancer treatment, and suggest that high-dose VitC may be a promising combination strategy to convert cold tumours into hot tumours, further widening the therapeutic scope of immunotherapy

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It is known that there is a competition between GPx and Cat for H 2 O 2 as a substrate [59]

Cancer Res 72(2):402407 Shrimali RK et al (2010) Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer

Subcutaneous injection typically shows a somewhat slower peak due to depot formation under skin, though both routes are far faster than oral for peptides

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