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Key Takeaway: Mechanistic potency in a petri dish does not equate to clinical relevance

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The body interprets rapid fat loss as a significant stressor, releasing inflammatory mediators as part of the adaptive response

Unlike GLP-1 agonists, it targets amylin receptors, making it a unique tool for studying complementary appetite-regulating pathways

JAMA 324 , 879 (2020)
