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10.1038/sj.cdd.4401950 Cell Death Differ

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The theoretical basis is that macrophage polarization imbalance alone is sufficient to induce PAH (141), demonstrating the therapeutic potential of this approach

A pre-heparinized syringe was used to collect 300 L of blood sample from the lateral tail vein on day 1 at 0 (pre-dose), 0.08, 0.25, 0.5, 1, 2, 4, 8, 24, 48, and 72 h and on day 7 at 0 (pre-dose), 0.08, 0.25, 0.5, 1, 2, 4, 8, 24, 48, as well as 72 h after test substance administration