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Cardiac tissue engineering (CTE), through an appropriate combination of cells, scaffold and signals, aims to bioengineer new and functional cardiac tissue, which could be used for tissue repair, patient specific drug screening as well as disease modeling, thus representing a new prospect to treat one of the most fatal cardiovascular diseases (Zammaretti and Jaconi, 2004)

Zhang K, Han X, Fu Y, Khan Z, Zhang B, Bi J, et al

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It was first isolated in 1974 from the cerebral venous blood of rabbits in a sleep state by Monnier and colleagues, making it one of the earlier identified endogenous neuropeptides associated with sleep-wake cycle regulation research

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