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Ascorbate potentiates the cytotoxicity of menadione leading to an oxidative stress that kills cancer cells by a non-apoptotic caspase-3 independent form of cell death

The TCA cycle is an aerobic cycle, and therefore a lack of oxygen would preclude synthesis of succinyl-CoA and hence of heme

Individuals who are deficient in MPO are generally healthy but have a mildly increased risk of life-threatening infections and inflammatory diseases

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