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Voriconazole, the second line of treatment, can cause hepatotoxicity with its prolonged use [44]
This ensures consistent quality control regardless of the order time

After centrifugation, fractions were removed from the gradients, 500 l per fraction

Given that HD affects different regions of the brain, its typical clinical manifestations include motor and cognitive disorders, as well as mental and behavioral abnormalities

This approach avoids the trauma of injections while capitalizing on the unique advantages of the oral route [254]

Since AUC sedimentation velocity (SV-AUC, where the rotor is spun at sufficiently high speed to allow measurement of the rate at which macromolecules move through a solution under high centrifugal force) and sedimentation equilibrium (SE-AUC, where the rotor speed is lower permitting to reach a state of equilibrium, where the centrifugal force driving sedimentation is balanced by diffusion) provide crucial information about the macromolecular properties, such as molecular weight, sedimentation, diffusion, frictional coefficients, shape, and formation of protein complexes, this technique rapidly became a major tool for the analysis of polymers, colloids, and proteins (Clfen, 2023)