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Hijaz and Volpicelli-Daley discuss how -synuclein aggregation, particularly in regions like the hippocampus, contributes to cognitive deficits in PD 104

More recently, a small uncontrolled study in five patients with mild-to-moderate AD reported cognitive improvement, measured by the Mini-Mental Status Examination, following supplementation with 300 mg/day of benfotiamine for 18 months (72)

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The dosage is typically adjusted based on individual patient needs and treatment response

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