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In order to elucidate this multifaceted clinical syndrome, complex pre-clinical models approximating the human reality are needed

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In agreement with these findings, Abd-Elrazek and Ahmed-Farid found that L-carnitine significantly decreased busulfan-induced elevated oxidative stress markers (MDA, glutathione disulfide (GSSG), nitric oxide (NO), and 8-hydroxyguanosine (8-HdG)) and significantly increased busulfan-induced glutathione (GSH) with antioxidant activity (53)

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