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Unlike classical forms of cell death, such as necrosis and apoptosis, ferroptosis is driven by an iron-catalyzed process [8]

384,403 In nanodiscs, both sides of the lipid membrane are exposed to the CFE reaction, which enables the study of both extracellular ligand binding and cytosolic activity of proteins without concern for orientation in the membrane

Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties

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Tu J, Le GY, Ballard HJ (2010) Involvement of the cystic fibrosis transmembrane conductance regulator in the acidosis-induced efflux of ATP from rat skeletal muscle

doi: 10.1038/nature14029 38 ScorttiM.MonzoH