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Neurotoxic reactive astrocytes are induced by activated microglia

A.ZegzoutiH.RamassamyS.LatcheA.PechJ.-C.et al (1998)
Furthermore, NO increases blood flow by relaxing the smooth vascular muscle and abdominal, and central obesity leads to an imbalanced production of fat-derived metabolic products, hormones, and adipokines that predispose to a state endothelial dysfunction, activating NADPH oxidase [67]

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A) Mitochondrial generation of superoxide is a characteristic feature of APAP-induced hepatocyte cell death, which reacts with nitric oxide to form the highly reactive oxidant and nitrating species peroxynitrite, causing extensive protein nitration in mitochondria
