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2,3 In REDEFINE 1, adverse events were mainly gastrointestinal, (79.6% in the CagriSema group vs 39.9% with placebo) including nausea (55% vs 12.6%), constipation (30.7% vs 11.6%), and vomiting (26.1% vs 4.1%)

Research indicates that cellular senescence refers to the loss of cell division and normal functional capabilities, making it the basic unit of biological aging (Barnes et al., 2019)

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Third, as expected, people with MS with significant objective disability progression over the follow-up period reported greater physical limitations, but without any corresponding decline in their psychosocial health