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96 The major endogenous nonenzymatic low-molecular-mass antioxidants include N-acetylcysteine, glutathione, uric acid, melatonin, coenzyme Q and others

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Indeed, if reduced GSH combines with disulfide bridges on extracellular proteins, it then becomes obvious that its extracellular concentration drops, but then the extracellular GSH concentration takes into account only free GSH, which cannot be used as a reference for GSH excreted by cells