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PARP2 has a catalytic structural domain similar to that of RARP1, and is essential for several cellular processes in an NAD + -dependent manner, including DNA repair and transcriptional regulation [56,57,58]

The purpose of this circuit is to remove waste products and toxins from the body

GSH TIPS THE SCALES BETWEEN SURVIVAL AND CELL DEATH The ROS-mediated intrinsic pathway of apoptosis disclosed that the intracellular amount of GSH could determine the capability of the cell to undergo apoptosis

10.1016/j.jep.2014.03.059 91 HuangE

Mandal et al., 2012), and preclinical studies have reported that GSH can protect against neuronal damage by different mechanisms, including activation of nerve growth factor, glial cell-derived neurotrophic factor, nitric oxide synthase, and choline acetyl transferase (Haddad et al., 2021

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