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HDGF is also known to be expressed endogenously in endothelial cells and to induce angiogenesis exogenously (26)

Scientific References & Further Reading The HPA Axis and Sleep: Research published in the Journal of Clinical Endocrinology & Metabolism highlights how chronic activation of the Hypothalamic-Pituitary-Adrenal axis leads to elevated evening cortisol and severe sleep fragmentation

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Studies have documented analgesic effects comparable to moderate doses of conventional pain medications in animal models, with prolonged duration of action extending beyond the peptide's short plasma half-life suggesting central nervous system mechanisms of action