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Methods Compounds for high-throughput screening For the similarity search and expanded screening, a diverse library of small-molecule compounds (1,000,000) from Asinex, Enamine and in-house collection was used

In the kynurenine pathway, an action of pro-inflammatory cytokines in microglia is to increase the action of the enzymes that participate in the pathway of quinolinic acid (QA), a neurotoxic metabolite

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(2023) 74:e12842

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These tumors exhibit dependencies on serine hydroxymethyltransferase (SHMT)-mediated pathways that represent novel therapeutic vulnerabilities [64, 65]