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NF-B is also involved in ethanol-induced neuroinflammation (Zou and Crews, The hypothalamus is one of the brain regions that undergoes more pathophysiological changes during excessive alcohol intake (Barson and Leibowitz, The MC system has been linked for many years with anti-inflammatory effects in the brain (Macaluso et al., via MC4R in these neuroinflammation-related cells (Caruso et al., Although we hypothesized that the activation of MC4R in the brain inhibits NF-B activity and neuroinflammation induced by ethanol (Flores-Bastas and Karahanian, BDNF is a neurotrophic factor that plays several roles in neurons growth and function

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7 Their position outside the body core allows the testes and epididymides to be kept at a lower-than-body temperature, which is optimal for sperm production and storage