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In the former, the V36 and R155 substitutions represent the backbone of resistance, whereas in the latter resistance is less frequent as it is preferentially associated with substitutions at position A156 that are associated with a decreased fitness of the variants [19], [20], [21]

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Furthermore, the exact mechanism by which a non-temporal cue triggers rhythms is still unknown, and this effect should also be tested in other tissues

Van Deventer H, Smith-Adao L, Collins NB, Grenfell M, Grundling A, Grundling PL, Impson D, Job N, Ltter M, Ollis D, Petersen C, Scherman P, Sieben E, Snaddon K, Tererai F, Van der Colff D

10.1186/s12864-020-06944-w Summary Keywords TMAO (trimethylamine oxide), MAFLD (metabolic associated fatty liver disease), trimethylamine, TMA precursor, FMO3, unfolded protein response, oxidative stress Citation Li X, Hong J, Wang Y, Pei M, Wang L and Gong Z (2021) Trimethylamine-N-Oxide Pathway: A Potential Target for the Treatment of MAFLD